Mediator complex interaction partners organize the transcriptional network that defines neural stem cells

The Mediator complex regulates transcription by connecting enhancers to promoters. Here, the authors purify Mediator from neural stem cells (NSCs), identify 75 novel protein-protein interaction partners and characterize the Mediator-interacting network that regulates transcription and establishes NS...

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Bibliographic Details
Main Authors: Marti Quevedo, Lize Meert, Mike R. Dekker, Dick H. W. Dekkers, Johannes H. Brandsma, Debbie L. C. van den Berg, Zeliha Ozgür, Wilfred F. J. van IJcken, Jeroen Demmers, Maarten Fornerod, Raymond A. Poot
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10502-8