Evidence of endoplasmic reticular stress in the spinal motor neurons exposed to CSF from sporadic amyotrophic lateral sclerosis patients

Evidence of endoplasmic reticular stress in the spinal motor neurons exposed to CSF from sporadic amyotrophic lateral sclerosis patients

We have earlier reported that intrathecal injection of cerebrospinal fluid (CSF) from sporadic Amyotrophic Lateral Sclerosis patients (ALS-CSF) into neonatal rats and supplementation of rat spinal cord cultures with ALS-CSF induces motor neuron degeneration via aberrant neurofilament phosphorylation...

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Bibliographic Details
Main Authors: K. Vijayalakshmi, Phalguni Anand Alladi, Shampa Ghosh, V.K. Prasanna, B.C. Sagar, A. Nalini, T.N. Sathyaprabha, T.R. Raju
Format: Article
Language:English
Published: Elsevier 2011-03-01
Series:Neurobiology of Disease
Subjects:
NSC-34 motor neuron cell line
Sporadic Amyotrophic Lateral Sclerosis
GRP-78 and caspase-12
Electron microscopy
Immunocyto/histochemistry
Western blotting
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110003980

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http://www.sciencedirect.com/science/article/pii/S0969996110003980

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