NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug

NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug

<p>Abstract</p> <p>Background</p> <p>Most DNA-damaging chemotherapeutic agents activate the transcription factor nuclear factor κB (NF-κB). However, NF-κB activation can either protect from or contribute to the growth suppressive effects of the agent. We previously show...

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Bibliographic Details
Main Authors: Caporali Simona, Levati Lauretta, Graziani Grazia, Muzi Alessia, Atzori Maria Grazia, Bonmassar Enzo, Palmieri Giuseppe, Ascierto Paolo A, D’Atri Stefania
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Journal of Translational Medicine
Subjects:
Nuclear factor κB
AKT
Temozolomide
NEMO binding domain peptide
Cell proliferation
Cell senescence
Online Access:http://www.translational-medicine.com/content/10/1/252

Internet

http://www.translational-medicine.com/content/10/1/252

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