JRAB/MICAL-L2 undergoes liquid–liquid phase separation to form tubular recycling endosomes

JRAB/MICAL-L2 undergoes liquid–liquid phase separation to form tubular recycling endosomes

Sakane et al. demonstrate that JRAB/MICAL-L2, an effector protein of Rab8 and Rab13, induces endosomal tubulation in HeLa cells depending on its closed conformation caused by an activated Rab8A. JRAB/MICAL-L2 undergoes liquid-liquid phase separation when overexpressed, which precedes its interaction...

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Bibliographic Details
Main Authors: Ayuko Sakane, Taka-aki Yano, Takayuki Uchihashi, Kazuki Horikawa, Yusuke Hara, Issei Imoto, Shusaku Kurisu, Hiroshi Yamada, Kohji Takei, Takuya Sasaki
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02080-7

Internet

https://doi.org/10.1038/s42003-021-02080-7

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