Temporal regulation of protein O‐GlcNAc levels during pressure‐overload cardiac hypertrophy

Temporal regulation of protein O‐GlcNAc levels during pressure‐overload cardiac hypertrophy

Abstract Protein posttranslational modifications (PTMs) by O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) rise during pressure‐overload hypertrophy (POH) to affect hypertrophic growth. The hexosamine biosynthesis pathway (HBP) branches from glycolysis to make the moiety for O‐GlcNAcylation. It is specula...

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Bibliographic Details
Main Authors: Wei Zhong Zhu, Dolena Ledee, Aaron K. Olson
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Physiological Reports
Subjects:
Cardiac hypertrophy
GFAT
glucose metabolism
hexosamine biosynthesis pathway
O‐GlcNAc
pressure‐overload hypertrophy
Online Access:https://doi.org/10.14814/phy2.14965

Internet

https://doi.org/10.14814/phy2.14965

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