Increased primaquine total dose prevents Plasmodium vivax relapses in patients with impaired CYP2D6 activity: report of three cases

Increased primaquine total dose prevents Plasmodium vivax relapses in patients with impaired CYP2D6 activity: report of three cases

Abstract Background The relapsing nature of Plasmodium vivax infection is a major barrier to its control and elimination. Factors such as adequate dosing, adherence, drug quality, and pharmacogenetics can impact the effectiveness of radical cure of P. vivax and need to be adequately evaluated. CYP2D...

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Bibliographic Details
Main Authors: Anielle de Pina-Costa, Ana Carolina Rios Silvino, Edwiges Motta dos Santos, Renata Saraiva Pedro, José Moreira, Gabriela Liseth Umana, Ana Danielle Tavares da Silva, Otília Helena Lupi da Rosa Santos, Karina Medeiros de Deus Henriques, Cláudio Tadeu Daniel-Ribeiro, Patrícia Brasil, Tais Nobrega Sousa, André M. Siqueira
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Malaria Journal
Subjects:
Plasmodium vivax
Relapses
CYP2D6
Primaquine
Radical cure
Online Access:https://doi.org/10.1186/s12936-021-03869-x

Internet

https://doi.org/10.1186/s12936-021-03869-x

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