Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses

Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses

Ebola virus (EBOV), the causative pathogen of the deadly EBOV disease (EVD), can be transmitted via sexual transmission. Seminal amyloid fibrils have been found enhancers of EBOV infection. Currently, limited preventive vaccine or therapeutic is available to block EBOV infection through sexual inter...

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Bibliographic Details
Main Authors: Mengjie Qiu, Zhaofeng Li, Yuliu Chen, Jiayin Guo, Wei Xu, Tao Qi, Yurong Qiu, Jianxin Pang, Lin Li, Shuwen Liu, Suiyi Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Microbiology
Subjects:
Ebola virus
tolcapone
semen-derived enhancer of viral infection (SEVI)
sexual transmission
entry inhibitor
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00504/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00504/full

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