Chloroquine is grossly under dosed in young children with malaria: implications for drug resistance.

Plasmodium falciparum malaria is treated with 25 mg/kg of chloroquine (CQ) irrespective of age. Theoretically, CQ should be dosed according to body surface area (BSA). The effect of dosing CQ according to BSA has not been determined but doubling the dose per kg doubled the efficacy of CQ in children...

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Bibliographic Details
Main Authors: Johan Ursing, Staffan Eksborg, Lars Rombo, Yngve Bergqvist, Daniel Blessborn, Amabelia Rodrigues, Poul-Erik Kofoed
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3900653?pdf=render