Comparative assessment of strategies to identify similar ligand-binding pockets in proteins
Abstract Background Detecting similar ligand-binding sites in globally unrelated proteins has a wide range of applications in modern drug discovery, including drug repurposing, the prediction of side effects, and drug-target interactions. Although a number of techniques to compare binding pockets ha...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-03-01
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Series: | BMC Bioinformatics |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12859-018-2109-2 |