Comparative assessment of strategies to identify similar ligand-binding pockets in proteins

Comparative assessment of strategies to identify similar ligand-binding pockets in proteins

Abstract Background Detecting similar ligand-binding sites in globally unrelated proteins has a wide range of applications in modern drug discovery, including drug repurposing, the prediction of side effects, and drug-target interactions. Although a number of techniques to compare binding pockets ha...

Full description

Bibliographic Details
Main Authors: Rajiv Gandhi Govindaraj, Michal Brylinski
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Bioinformatics
Subjects:
Pocket comparison
Ligand-binding sites
Structure-based virtual screening
Drug repurposing
Drug repositioning
Drug design
Online Access:http://link.springer.com/article/10.1186/s12859-018-2109-2

Internet

http://link.springer.com/article/10.1186/s12859-018-2109-2

Similar Items