A mitochondrial-targeted peptide ameliorated podocyte apoptosis through a HOCl-alb-enhanced and mitochondria-dependent signalling pathway in diabetic rats and in vitro

A mitochondrial-targeted peptide ameliorated podocyte apoptosis through a HOCl-alb-enhanced and mitochondria-dependent signalling pathway in diabetic rats and in vitro

Mitochondria play important roles in the development of diabetic kidney disease (DKD). The SS peptide is a tetrapeptide that is located and accumulated in the inner mitochondrial membrane; it reduces reactive oxygen species (ROS) and prevents mitochondrial dysfunction. Podocytes are key cellular com...

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Bibliographic Details
Main Authors: Xiaoqiao Wang, Dongdong Tang, Yaowei Zou, Xiaoyu Wu, Yihua Chen, Hongying Li, Siqi Chen, Yue Shi, Hongxin Niu
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
podocyte apoptosis
mitochondria
antioxidant peptide
hypochlorite-modified albumin
diabetic kidney disease
Online Access:http://dx.doi.org/10.1080/14756366.2018.1488697

Internet

http://dx.doi.org/10.1080/14756366.2018.1488697

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