Role of MAML1 in targeted therapy against the esophageal cancer stem cells

Role of MAML1 in targeted therapy against the esophageal cancer stem cells

Abstract Background Esophageal cancer is the sixth-leading cause of cancer-related deaths worldwide. Cancer stem cells (CSCs) are the main reason for tumor relapse in esophageal squamous cell carcinoma (ESCC). The NOTCH pathway is important in preservation of CSCs, therefore it is possible to target...

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Bibliographic Details
Main Authors: Meysam Moghbeli, Hooman Mosannen Mozaffari, Bahram Memar, Mohammad Mahdi Forghanifard, Mehran Gholamin, Mohammad Reza Abbaszadegan
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Translational Medicine
Subjects:
Cancer stem cell
CD44
ESCC
NOTCH pathway
MAML1
ABC transporter
Online Access:http://link.springer.com/article/10.1186/s12967-019-1876-5

Internet

http://link.springer.com/article/10.1186/s12967-019-1876-5

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