Alpha-beta transition induced by C18-conjugation of polyalanine and its implication in aqueous solution behavior of poly(ethylene glycol)-polyalanine block copolymers

Alpha-beta transition induced by C18-conjugation of polyalanine and its implication in aqueous solution behavior of poly(ethylene glycol)-polyalanine block copolymers

Abstract Background The aqueous solution behavior of thermosensitive PEG-PA block copolymers as well as secondary structure of PA is expected to significantly change through modification of the hydrophobic PA by long chain alkyl (C18) groups with different configurations. Method Oleoyl and stearoyl...

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Bibliographic Details
Main Authors: Min Hee Park, Jinkyung Park, Hyun Jung Lee, Byeongmoon Jeong
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Biomaterials Research
Subjects:
Hydrophobic conjugation
Alpha-beta transition of polypeptide, solution behavior
Online Access:https://doi.org/10.1186/s40824-020-00200-8

Internet

https://doi.org/10.1186/s40824-020-00200-8

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