Huoxin pill attenuates myocardial infarction-induced apoptosis and fibrosis via suppression of p53 and TGF-β1/Smad2/3 pathways

Huoxin pill attenuates myocardial infarction-induced apoptosis and fibrosis via suppression of p53 and TGF-β1/Smad2/3 pathways

Huoxin Pill (HXP), a Traditional Chinese Medicine, is used widely to treat patients with coronary heart disease and angina pectoris in China. However, the underlying protective mechanism of HXP on cardiac apoptosis and fibrosis has never been evaluated. Therefore, the aim of this study was to invest...

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Bibliographic Details
Main Authors: Zhiqing Shen, Aling Shen, Xiaoping Chen, Xiangyan Wu, Jianfeng Chu, Ying Cheng, Meizhong Peng, Youqin Chen, Nathaniel Weygant, Meizhu Wu, Xiaoying Lin, Jun Peng, Keji Chen
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Huoxin pill
MI
Cardiac fibrosis
Cardiac apoptosis
TGF-β1/Smads pathway
p53
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220308118

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http://www.sciencedirect.com/science/article/pii/S0753332220308118

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