Inclusion complexes of β-cyclodextrin with tricyclic drugs: an X-ray diffraction, NMR and molecular dynamics study

Inclusion complexes of β-cyclodextrin with tricyclic drugs: an X-ray diffraction, NMR and molecular dynamics study

Tricyclic fused-ring cyclobenzaprine (1) and amitriptyline (2) form 1:1 inclusion complexes with β-cyclodextrin (β-CD) in the solid state and in water solution. Rotating frame NOE experiments (ROESY) showed the same geometry of inclusion for both 1/β-CD and 2/β-CD complexes, with the aromatic ring s...

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Bibliographic Details
Main Authors: Franca Castiglione, Fabio Ganazzoli, Luciana Malpezzi, Andrea Mele, Walter Panzeri, Giuseppina Raffaini
Format: Article
Language:English
Published: Beilstein-Institut 2017-04-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
amitriptyline
β-cyclodextrin
crystal structure
cyclobenzaprine
molecular dynamics simulations
NOE
Online Access:https://doi.org/10.3762/bjoc.13.70

Internet

https://doi.org/10.3762/bjoc.13.70

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