Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer

Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer

Germline precursors and intermediates of broadly neutralizing antibodies (bNAbs) are essential to the understanding of humoral response to HIV-1 infection and B-cell lineage vaccine design. Using a native-like gp140 trimer probe, we examined antibody libraries constructed from donor-17, the source o...

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Bibliographic Details
Main Authors: Linling He, Xiaohe Lin, Natalia de Val, Karen L. Saye-Francisco, Colin J. Mann, Ryan Augst, Charles D. Morris, Parisa Azadnia, Bin Zhou, Devin Sok, Gabriel Ozorowski, Andrew B. Ward, Dennis R. Burton, Jiang Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
antibody phage display
B-cell lineage development
broadly neutralizing antibodies
HIV-1 vaccine design
native-like trimer
next-generation sequencing
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01025/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01025/full

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