Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer
Germline precursors and intermediates of broadly neutralizing antibodies (bNAbs) are essential to the understanding of humoral response to HIV-1 infection and B-cell lineage vaccine design. Using a native-like gp140 trimer probe, we examined antibody libraries constructed from donor-17, the source o...
Main Authors: | Linling He, Xiaohe Lin, Natalia de Val, Karen L. Saye-Francisco, Colin J. Mann, Ryan Augst, Charles D. Morris, Parisa Azadnia, Bin Zhou, Devin Sok, Gabriel Ozorowski, Andrew B. Ward, Dennis R. Burton, Jiang Zhu |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2017-08-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01025/full |
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