Cerebral cavernous malformations: Review of the genetic and protein-protein interactions resulting in disease pathogenesis
Mutations in the genes KRIT1, CCM2, and PDCD10 are known to result in the formation of cerebral cavernous malformations (CCMs). CCMs are intracranial lesions comprised of aberrantly enlarged cavernous endothelial channels that can result in cerebral hemorrhage, seizures, and neurologic deficits. Alt...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-11-01
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| Series: | Frontiers in Surgery |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fsurg.2016.00060/full |