SIV vpx is essential for macrophage infection but not for development of AIDS.
Analysis of rhesus macaques infected with a vpx deletion mutant virus of simian immunodeficiency virus mac239 (SIVΔvpx) demonstrates that Vpx is essential for efficient monocyte/macrophage infection in vivo but is not necessary for development of AIDS. To compare myeloid-lineage cell infection in mo...
Main Authors: | Susan V Westmoreland, A Peter Converse, Kasia Hrecka, Mollie Hurley, Heather Knight, Michael Piatak, Jeffrey Lifson, Keith G Mansfield, Jacek Skowronski, Ronald C Desrosiers |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3897363?pdf=render |
Similar Items
-
Limelight on two HIV/SIV accessory proteins in macrophage infection: Is Vpx overshadowing Vpr?
by: Maudet Claire, et al.
Published: (2010-04-01) -
SAMHD1-dependent and -independent functions of HIV-2/SIV Vpx protein
by: Mikako eFujita, et al.
Published: (2012-08-01) -
ADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challenge.
by: Michael D Alpert, et al.
Published: (2012-01-01) -
The HIV-2/SIV<sub>SM </sub>Vpx protein and an antiviral restriction in primary myeloid cells
by: Durand Stephanie, et al.
Published: (2009-09-01) -
Immunization with single-cycle SIV significantly reduces viral loads after an intravenous challenge with SIV(mac)239.
by: Bin Jia, et al.
Published: (2009-01-01)