White matter alterations in the internal capsule and psychomotor impairment in melancholic depression.

Emerging evidence suggests that structural brain abnormalities may play a role in the pathophysiology of melancholic depression. We set out to test whether diffusion-derived estimates of white matter structure were disrupted in melancholia in regions underpinning psychomotor function. We hypothesize...

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Bibliographic Details
Main Authors: Matthew P Hyett, Alistair Perry, Michael Breakspear, Wei Wen, Gordon B Parker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5908181?pdf=render