Structural Probing and Molecular Modeling of the A3 Adenosine Receptor: A Focus on Agonist Binding

Structural Probing and Molecular Modeling of the A3 Adenosine Receptor: A Focus on Agonist Binding

Adenosine is an endogenous modulator exerting its functions through the activation of four adenosine receptor (AR) subtypes, termed A1, A2A, A2B and A3, which belong to the G protein-coupled receptor (GPCR) superfamily. The human A3AR (hA3AR) subtype is implicated in several cytoprotective functions...

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Bibliographic Details
Main Authors: Antonella Ciancetta, Kenneth A. Jacobson
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Molecules
Subjects:
G protein-coupled receptor
site-directed mutagenesis
homology modeling
adenosine receptor
structure-activity relationship
nucleoside
docking
molecular dynamics
agonist
drug discovery
virtual screening
Online Access:http://www.mdpi.com/1420-3049/22/3/449

Internet

http://www.mdpi.com/1420-3049/22/3/449

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