Glucotoxicity induces abnormal glucagon secretion through impaired insulin signaling in InR1G cells.

Glucotoxicity induces abnormal glucagon secretion through impaired insulin signaling in InR1G cells.

The significance of glucagon in the pathophysiology of diabetes mellitus is widely recognized, but the mechanisms underlying dysregulated glucagon secretion are still unclear. Here, we explored the molecular mechanisms of glucagon dysregulation, using an in vitro model. Hamster-derived glucagon-secr...

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Bibliographic Details
Main Authors: Takashi Katsura, Dan Kawamori, Eri Aida, Taka-Aki Matsuoka, Iichiro Shimomura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5398759?pdf=render

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http://europepmc.org/articles/PMC5398759?pdf=render

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