DNA Damage Measured by the Comet Assay in Head and Neck Cancer Patients Treated with Tirapazamine

DNA Damage Measured by the Comet Assay in Head and Neck Cancer Patients Treated with Tirapazamine

Tirapazamine (TPZ) [3-amino -1,2,4-benzotriazine 1,4-dioxide, SR4233, WIN 59075, and Tirazone™] is a novel anticancer drug that is selectively activated by the low oxygen environment in solid tumors. By killing the radioresistant hypoxic cells, TPZ potentiates the antitumor efficacy of fractionated...

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Bibliographic Details
Main Authors: Mary Jo Dorie, Mary S. Kovacs, Edward C. Gabalski, Markus Adam, Quynh-T Le, Daniel A. Bloch, Harlan A. Pinto, David J. Terris, J. Martin Brown
Format: Article
Language:English
Published: Elsevier 1999-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
tirapazamine
comet assay
hypoxia
eppendorf
radiotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558699800189

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http://www.sciencedirect.com/science/article/pii/S1476558699800189

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