Personalized Medicine in Gastrointestinal Stromal Tumor (GIST): Clinical Implications of the Somatic and Germline DNA Analysis

Personalized Medicine in Gastrointestinal Stromal Tumor (GIST): Clinical Implications of the Somatic and Germline DNA Analysis

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. They are characterized by gain of function mutations in KIT or PDGFRA tyrosine kinase receptors, with their consequent constitutive activation. The gold standard therapy is imatinib that offe...

Full description

Bibliographic Details
Main Authors: Gloria Ravegnini, Margherita Nannini, Giulia Sammarini, Annalisa Astolfi, Guido Biasco, Maria A. Pantaleo, Patrizia Hrelia, Sabrina Angelini
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:International Journal of Molecular Sciences
Subjects:
GIST
KIT/PDGFRA mutant GIST
WT-GIST
personalized therapy
biomarkers
drug resistance
polymorphisms
Online Access:http://www.mdpi.com/1422-0067/16/7/15592

Internet

http://www.mdpi.com/1422-0067/16/7/15592

Similar Items