Non-linear optical imaging of atherosclerotic plaques in the context of SIV and HIV infection prominently detects crystalline cholesterol esters.

Chronic HIV infection may exacerbate atherosclerotic vascular disease, which at advanced stages presents as necrotic plaques rich in crystalline cholesterol. Such lesions can catastrophically rupture precipitating myocardial infarct and stroke, now important causes of mortality in those living with...

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Bibliographic Details
Main Authors: Min Hi Park, Jeffrey L Suhalim, Firas Elmastour, Santu K Singha, Tadashi Imafuku, Ramanathan Venkatnarayan, Anette Christ, Alena Grebe, Sarah A Oppelt, Dmitri Sviridov, Michael Bukrinsky, Eicke Latz, Eric O Potma, Michael L Fitzgerald
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0251599