Amyloid-β, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data

Amyloid-β, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data

We investigated whether amyloid-β (Aβ) and tau affected cognition in cognitively normal (CN) individuals, and whether norms for neuropsychological tests based on biomarker-negative individuals would improve early detection of dementia. We included 907 CN individuals from 8 European cohorts and from...

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Bibliographic Details
Main Authors: Isabelle Bos, Stephanie J. B. Vos, Willemijn J. Jansen, Rik Vandenberghe, Silvy Gabel, Ainara Estanga, Mirian Ecay-Torres, Jori Tomassen, Anouk den Braber, Alberto Lleó, Isabel Sala, Anders Wallin, Petronella Kettunen, José L. Molinuevo, Lorena Rami, Gaël Chetelat, Vincent de la Sayette, Magda Tsolaki, Yvonne Freund-Levi, Peter Johannsen, The Alzheimer's Disease Neuroimaging Initiative, Gerald P. Novak, Inez Ramakers, Frans R. Verhey, Pieter Jelle Visser
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer's disease
amyloid-beta
tau
cognition
neuropsychological examination
normative data
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00193/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2018.00193/full

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