Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression.

Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression.

The efficacy of anti-HER2 therapeutics, such as lapatinib and trastuzumab, is limited by primary and acquired resistance. Cellular adaptations that allow breast cancer cell to survive prolonged HER2 inhibition include de-repression of the transcription factor FOXO3A with consequent estrogen receptor...

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Bibliographic Details
Main Authors: Alessio Nencioni, Michele Cea, Anna Garuti, Mario Passalacqua, Lizzia Raffaghello, Debora Soncini, Eva Moran, Gabriele Zoppoli, Vito Pistoia, Franco Patrone, Alberto Ballestrero
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2814867?pdf=render

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http://europepmc.org/articles/PMC2814867?pdf=render

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