Rationale and design of mDOT-HuA study: a randomized trial to assess the effect of mobile-directly observed therapy on adherence to hydroxyurea in adults with sickle cell anemia in Tanzania

Rationale and design of mDOT-HuA study: a randomized trial to assess the effect of mobile-directly observed therapy on adherence to hydroxyurea in adults with sickle cell anemia in Tanzania

Abstract Background Hydroxyurea (HU) has been demonstrated to be efficacious in reducing complications in individuals with sickle cell anemia (SCA) but poor adherence is a barrier. Directly Observed Therapy (DOT) has been shown to improve adherence in various chronic diseases but there is limited da...

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Bibliographic Details
Main Authors: Abel Makubi, Philip Sasi, Mariam Ngaeje, Enrico M. Novelli, Bruno P. Mmbando, Mark T. Gladwin, Julie Makani
Format: Article
Language:English
Published: BMC 2016-10-01
Series:BMC Medical Research Methodology
Subjects:
Sickle cell disease
Hydroxyurea
Adherence
Medication possession ratio
Randomized trial
Online Access:http://link.springer.com/article/10.1186/s12874-016-0245-9

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http://link.springer.com/article/10.1186/s12874-016-0245-9

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