Molecular Dissection of Induced Platinum Resistance through Functional and Gene Expression Analysis in a Cell Culture Model of Bladder Cancer.

Molecular Dissection of Induced Platinum Resistance through Functional and Gene Expression Analysis in a Cell Culture Model of Bladder Cancer.

We report herein the development, functional and molecular characterization of an isogenic, paired bladder cancer cell culture model system for studying platinum drug resistance. The 5637 human bladder cancer cell line was cultured over ten months with stepwise increases in oxaliplatin concentration...

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Bibliographic Details
Main Authors: Sisi Wang, Hongyong Zhang, Tiffany M Scharadin, Maike Zimmermann, Bin Hu, Amy Wang Pan, Ruth Vinall, Tzu-yin Lin, George Cimino, Patrick Chain, Momchilo Vuyisich, Cheryl Gleasner, Kim Mcmurry, Michael Malfatti, Kenneth Turteltaub, Ralph de Vere White, Chong-xian Pan, Paul T Henderson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4723083?pdf=render

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http://europepmc.org/articles/PMC4723083?pdf=render

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