Sugar phosphate activation of the stress sensor eIF2B

Sugar phosphate activation of the stress sensor eIF2B

The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link between nutrient status and the rate of protein synthe...

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Bibliographic Details
Main Authors: Qi Hao, Jin-Mi Heo, Boguslaw P. Nocek, Kevin G. Hicks, Vincent S. Stoll, Clint Remarcik, Sean Hackett, Lauren LeBon, Rinku Jain, Dan Eaton, Jared Rutter, Yao Liang Wong, Carmela Sidrauski
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23836-z

Internet

https://doi.org/10.1038/s41467-021-23836-z

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