Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish

Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish

The aberrant activation of developmental processes triggers diverse cancer types. Chordoma is a rare, aggressive tumor arising from transformed notochord remnants. Several potentially oncogenic factors have been found to be deregulated in chordoma, yet causation remains uncertain. In particular, sus...

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Bibliographic Details
Main Authors: Gianluca D'Agati, Elena María Cabello, Karl Frontzek, Elisabeth J. Rushing, Robin Klemm, Mark D. Robinson, Richard M. White, Christian Mosimann, Alexa Burger
Format: Article
Language:English
Published: The Company of Biologists 2019-07-01
Series:Disease Models & Mechanisms
Subjects:
Notochord
TBXT
RTK
Cancer
Danio rerio
In vivo models
Online Access:http://dmm.biologists.org/content/12/7/dmm039545

Internet

http://dmm.biologists.org/content/12/7/dmm039545

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