Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway.

Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway.

Idiopathic pulmonary fibrosis (IPF) is a chronic disease with high mortality and is refractory to treatment. Pulmonary macrophages can both promote and repress fibrosis, however molecular mechanisms regulating macrophage functions during fibrosis remain poorly understood. FOXM1 is a transcription fa...

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Bibliographic Details
Main Authors: Chinmayee Goda, David Balli, Markaisa Black, David Milewski, Tien Le, Vladimir Ustiyan, Xiaomeng Ren, Vladimir V Kalinichenko, Tanya V Kalin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-04-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008692

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https://doi.org/10.1371/journal.pgen.1008692

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