Pharmacologic Targeting of BET Proteins Attenuates Hyperuricemic Nephropathy in Rats

Pharmacologic Targeting of BET Proteins Attenuates Hyperuricemic Nephropathy in Rats

Hyperuricemia is an independent risk factor for renal damage and promotes the progression of chronic kidney disease. In this study, we investigated the effect of I-BET151, a small-molecule inhibitor targeting the bromodomain and extraterminal (BET) proteins, on the development of hyperuricemic nephr...

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Bibliographic Details
Main Authors: Chongxiang Xiong, Jin Deng, Xin Wang, Xiaofei Shao, Qin Zhou, Hequn Zou, Shougang Zhuang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
bromodomain and extra-terminal proteins
hyperuricemic nephropathy
I-BET151
renal fibrosis
epithelial-to-mesenchymal transition
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.636154/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.636154/full

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