Biodegradable Nanoparticles of mPEG-PLGA-PLL Triblock Copolymers as Novel Non-Viral Vectors for Improving siRNA Delivery and Gene Silencing

Biodegradable Nanoparticles of mPEG-PLGA-PLL Triblock Copolymers as Novel Non-Viral Vectors for Improving siRNA Delivery and Gene Silencing

Degradation of mRNA by RNA interference is one of the most powerful and specific mechanisms for gene silencing. However, insufficient cellular uptake and poor stability have limited its usefulness. Here, we report efficient delivery of siRNA via the use of biodegradable nanoparticles (NPs) made from...

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Bibliographic Details
Main Authors: Qiu-Sheng Shi, Pei-Feng Liu, Ming-Jie Zhu, Chun-Hui Wang, Lian-Fang Du, You-Rong Duan, Jing Du, Ying Sun
Format: Article
Language:English
Published: MDPI AG 2012-01-01
Series:International Journal of Molecular Sciences
Subjects:
gene silencing
nanoparticles
PLGA
PLL
siRNA delivery
GFP
Online Access:http://www.mdpi.com/1422-0067/13/1/516/

Internet

http://www.mdpi.com/1422-0067/13/1/516/

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