Development and Validation of a Bioanalytical Method for the Simultaneous Determination of 14 Antiretroviral Drugs using Liquid Chromatography-Tandem Mass Spectrometry

Development and Validation of a Bioanalytical Method for the Simultaneous Determination of 14 Antiretroviral Drugs using Liquid Chromatography-Tandem Mass Spectrometry

OBJECTIVES: The aim was to develop and validate a LC-MS/MS assay to determine antiretrovirals in human plasma for routine therapeutic drug monitoring. METHODS: The selectivity, sensitivity, linearity, accuracy, precision, recovery, matrix effect, stability and dilution integrity and carry-over we...

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Bibliographic Details
Main Authors: Alper Daskapan, Kai van Hateren, Ymkje Stienstra, Jos Kosterink, Tjip van der Werf, Daan Touw, Jan-Willem Alffenaar
Format: Article
Language:English
Published: Betasciencepress Publishers 2018-04-01
Series:Journal of Applied Bioanalysis
Subjects:
lc-ms/ms
antiretrovirals
hiv
TDM
Online Access:https://doi.org/10.17145/jab.18.007

Internet

https://doi.org/10.17145/jab.18.007

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