FcγR Binding and ADCC Activity of Human IgG Allotypes

FcγR Binding and ADCC Activity of Human IgG Allotypes

Antibody dependent cellular cytotoxicity (ADCC) is an Fc-dependent effector function of IgG important for anti-viral immunity and anti-tumor therapies. NK-cell mediated ADCC is mainly triggered by IgG-subclasses IgG1 and IgG3 through the IgG-Fc-receptor (FcγR) IIIa. Polymorphisms in the immunoglobul...

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Bibliographic Details
Main Authors: Steven W. de Taeye, Arthur E. H. Bentlage, Mirjam M. Mebius, Joyce I. Meesters, Suzanne Lissenberg-Thunnissen, David Falck, Thomas Sénard, Nima Salehi, Manfred Wuhrer, Janine Schuurman, Aran F. Labrijn, Theo Rispens, Gestur Vidarsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
antibodies
IgG polymorphism
Fc gamma receptor
antibody dependent cellular cytotoxicity
glycosylation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00740/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00740/full

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