Hexosamine biosynthetic pathway and O-GlcNAc-processing enzymes regulate daily rhythms in protein O-GlcNAcylation

Misalignment between lifestyle and the natural day-night cycle, such as mistimed eating, can negatively impact health. Here the authors show that mistimed feeding alters protein O-GlcNAcylation, a nutrient sensitive post-translational modification.

Bibliographic Details
Main Authors: Xianhui Liu, Ivana Blaženović, Adam J. Contreras, Thu M. Pham, Christine A. Tabuloc, Ying H. Li, Jian Ji, Oliver Fiehn, Joanna C. Chiu
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24301-7