Immunomodulatory Effects of Genetic Alterations Affecting the Kynurenine Pathway

Several enzymes and metabolites of the kynurenine pathway (KP) have immunomodulatory effects. Modulation of the activities and levels of these molecules might be of particular importance under disease conditions when the amelioration of overreacting immune responses is desired. Results obtained by t...

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Bibliographic Details
Main Authors: Fanni A. Boros, László Vécsei
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
IDO
TDO
KMO
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02570/full