Aspirin Induces Mitochondrial Ca<sup>2+ </sup>Remodeling in Tumor Cells via ROS‒Depolarization‒Voltage-Gated Ca<sup>2+</sup> Entry
Aspirin (acetylsalicylic acid) and its metabolite salicylate, have an anti-melanoma effect by evoking mitochondrial dysfunction through poorly understood mechanisms. Depolarization of the plasma membrane potential leads to voltage-gated Ca<sup>2+</sup> entry (VGCE) and caspase-3 activati...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-07-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/13/4771 |