Aspirin Induces Mitochondrial Ca<sup>2+ </sup>Remodeling in Tumor Cells via ROS‒Depolarization‒Voltage-Gated Ca<sup>2+</sup> Entry

Aspirin Induces Mitochondrial Ca<sup>2+ </sup>Remodeling in Tumor Cells via ROS‒Depolarization‒Voltage-Gated Ca<sup>2+</sup> Entry

Aspirin (acetylsalicylic acid) and its metabolite salicylate, have an anti-melanoma effect by evoking mitochondrial dysfunction through poorly understood mechanisms. Depolarization of the plasma membrane potential leads to voltage-gated Ca<sup>2+</sup> entry (VGCE) and caspase-3 activati...

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Bibliographic Details
Main Authors: Itsuho Fujikawa, Takashi Ando, Manami Suzuki-Karasaki, Miki Suzuki-Karasaki, Toyoko Ochiai, Yoshihiro Suzuki-Karasaki
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
aspirin
salicylate
melanoma
apoptosis
depolarization
mitochondria
Online Access:https://www.mdpi.com/1422-0067/21/13/4771

Internet

https://www.mdpi.com/1422-0067/21/13/4771

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