A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Humans with Arthritis

A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Humans with Arthritis

BackgroundCollagen XI (CXI) is a heterotrimeric molecule with triple helical structure in which the α3(XI) chain is identical to the α1(II) chain of collagen II (CII), but with extensive posttranslational modifications. CXI molecules are intermingled in the cartilage collagen fibers, which are mainl...

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Bibliographic Details
Main Authors: Dongmei Tong, Erik Lönnblom, Anthony C. Y. Yau, Kutty Selva Nandakumar, Bibo Liang, Changrong Ge, Johan Viljanen, Lei Li, Mirela Bãlan, Lars Klareskog, Andrei S. Chagin, Inger Gjertsson, Jan Kihlberg, Ming Zhao, Rikard Holmdahl
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
arthritis
autoantibody
collagen XI
CII
cross-reactive
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00451/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00451/full

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