Immune Profiles Identification by Vaccinomics After MVA Immunization in Randomized Clinical Study

Immune Profiles Identification by Vaccinomics After MVA Immunization in Randomized Clinical Study

BackgroundOur previous work has demonstrated the benefits of transcutaneous immunization in targeting Langerhans cells and preferentially inducing CD8 T-cell responses.MethodsIn this randomized phase Ib clinical trial including 20 HIV uninfected volunteers, we compared the safety and immunogenicity...

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Bibliographic Details
Main Authors: Jorge Sanchez, Elena Gonçalves, Anuska Llano, Pedro Gonzáles, María Fernández-Maldonado, Annika Vogt, Angele Soria, Susana Perez, Samandhy Cedeño, Marco Antonio Fernández, Julien Nourikyan, Simon de Bernard, Carmela Ganoza, Eric Pedruzzi, Olivia Bonduelle, Beatriz Mothe, Carmen E. Gòmez, Mariano Esteban, Felipe Garcia, Javier R. Lama, Christian Brander, Behazine Combadiere
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
immunogenicity
cutaneous vaccination
intramuscular route
vaccinia virus vector
transcriptome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.586124/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.586124/full

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