Fibroblast Activation Protein-α as a Target in the Bench-to-Bedside Diagnosis and Treatment of Tumors: A Narrative Review

Fibroblast Activation Protein-α as a Target in the Bench-to-Bedside Diagnosis and Treatment of Tumors: A Narrative Review

Fibroblast activation protein-α (FAP) is a type II integral serine protease that is specifically expressed by activated fibroblasts. Cancer-associated fibroblasts (CAFs) in the tumor stroma have an abundant and stable expression of FAP, which plays an important role in promoting tumor growth, invasi...

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Bibliographic Details
Main Authors: Lei Xin, Jinfang Gao, Ziliang Zheng, Yiyou Chen, Shuxin Lv, Zhikai Zhao, Chunhai Yu, Xiaotang Yang, Ruiping Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
cancer-associated fibroblast
FAP substrates
immunosuppressive
targeted therapy
nanomaterials
fibroblast activation protein-α
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.648187/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.648187/full

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