A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses

A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses

Although β-blockers can be used to eliminate stress-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), this treatment is unsuccessful in ∼25% of cases. Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) generated from these pat...

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Bibliographic Details
Main Authors: Marcela K. Preininger, Rajneesh Jha, Joshua T. Maxwell, Qingling Wu, Monalisa Singh, Bo Wang, Aarti Dalal, Zachary T. Mceachin, Wilfried Rossoll, Chadwick M. Hales, Peter S. Fischbach, Mary B. Wagner, Chunhui Xu
Format: Article
Language:English
Published: The Company of Biologists 2016-09-01
Series:Disease Models & Mechanisms
Subjects:
Arrhythmia models
Cardiomyocytes
Ca2+ handling
CPVT
iPSCs
Online Access:http://dmm.biologists.org/content/9/9/927

Internet

http://dmm.biologists.org/content/9/9/927

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