Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction

Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction

Advanced donor age is a risk factor for poor survival following lung transplantation. However, recent work identifying epigenetic determinants of aging has shown that biologic age may not always reflect chronologic age and that stressors can accelerate biologic aging. We hypothesized that lung allog...

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Bibliographic Details
Main Authors: Daniel T. Dugger, Daniel R. Calabrese, Ying Gao, Fred Deiter, Tasha Tsao, Julia Maheshwari, Steven R. Hays, Lorriana Leard, Mary Ellen Kleinhenz, Rupal Shah, Jeff Golden, Jasleen Kukreja, Erin D. Gordon, Jonathan P. Singer, John R. Greenland
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
lung
allograft
epigenetic
aging
primary graft dysfunction (PGD)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.704172/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.704172/full

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