Inhibition of CSF-1R supports T-cell mediated melanoma therapy.

Inhibition of CSF-1R supports T-cell mediated melanoma therapy.

Tumor associated macrophages (TAM) can promote angiogenesis, invasiveness and immunosuppression. The cytokine CSF-1 (or M-CSF) is an important factor of TAM recruitment and differentiation and several pharmacological agents targeting the CSF-1 receptor (CSF-1R) have been developed to regulate TAM in...

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Bibliographic Details
Main Authors: Marjolein Sluijter, Tetje C van der Sluis, Pieter A van der Velden, Mieke Versluis, Brian L West, Sjoerd H van der Burg, Thorbald van Hall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4128661?pdf=render

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http://europepmc.org/articles/PMC4128661?pdf=render

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