Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks
How factors involved in homologous recombination interact and function is a matter of interest. Here the authors use super-resolution imaging to describe the spatiotemporal dynamics of proteins associated with homologous recombination DNA repair in response to replication stress.
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-09-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-06435-3 |
id |
doaj-7dede67c47fa41e5b8e6f07d588a1c84 |
---|---|
record_format |
Article |
spelling |
doaj-7dede67c47fa41e5b8e6f07d588a1c842021-05-11T09:39:22ZengNature Publishing GroupNature Communications2041-17232018-09-019111510.1038/s41467-018-06435-3Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forksDonna R. Whelan0Wei Ting C. Lee1Yandong Yin2Dylan M. Ofri3Keria Bermudez-Hernandez4Sarah Keegan5David Fenyo6Eli Rothenberg7Department of Biochemistry and Molecular Pharmacology, Perlmutter Cancer Center, New York University School of MedicineDepartment of Biochemistry and Molecular Pharmacology, Perlmutter Cancer Center, New York University School of MedicineDepartment of Biochemistry and Molecular Pharmacology, Perlmutter Cancer Center, New York University School of MedicineDepartment of Biochemistry and Molecular Pharmacology, Perlmutter Cancer Center, New York University School of MedicineDepartment of Biochemistry and Molecular Pharmacology, Perlmutter Cancer Center, New York University School of MedicineDepartment of Biochemistry and Molecular Pharmacology, Perlmutter Cancer Center, New York University School of MedicineDepartment of Biochemistry and Molecular Pharmacology, Perlmutter Cancer Center, New York University School of MedicineDepartment of Biochemistry and Molecular Pharmacology, Perlmutter Cancer Center, New York University School of MedicineHow factors involved in homologous recombination interact and function is a matter of interest. Here the authors use super-resolution imaging to describe the spatiotemporal dynamics of proteins associated with homologous recombination DNA repair in response to replication stress.https://doi.org/10.1038/s41467-018-06435-3 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Donna R. Whelan Wei Ting C. Lee Yandong Yin Dylan M. Ofri Keria Bermudez-Hernandez Sarah Keegan David Fenyo Eli Rothenberg |
spellingShingle |
Donna R. Whelan Wei Ting C. Lee Yandong Yin Dylan M. Ofri Keria Bermudez-Hernandez Sarah Keegan David Fenyo Eli Rothenberg Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks Nature Communications |
author_facet |
Donna R. Whelan Wei Ting C. Lee Yandong Yin Dylan M. Ofri Keria Bermudez-Hernandez Sarah Keegan David Fenyo Eli Rothenberg |
author_sort |
Donna R. Whelan |
title |
Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks |
title_short |
Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks |
title_full |
Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks |
title_fullStr |
Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks |
title_full_unstemmed |
Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks |
title_sort |
spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-09-01 |
description |
How factors involved in homologous recombination interact and function is a matter of interest. Here the authors use super-resolution imaging to describe the spatiotemporal dynamics of proteins associated with homologous recombination DNA repair in response to replication stress. |
url |
https://doi.org/10.1038/s41467-018-06435-3 |
work_keys_str_mv |
AT donnarwhelan spatiotemporaldynamicsofhomologousrecombinationrepairatsinglecollapsedreplicationforks AT weitingclee spatiotemporaldynamicsofhomologousrecombinationrepairatsinglecollapsedreplicationforks AT yandongyin spatiotemporaldynamicsofhomologousrecombinationrepairatsinglecollapsedreplicationforks AT dylanmofri spatiotemporaldynamicsofhomologousrecombinationrepairatsinglecollapsedreplicationforks AT keriabermudezhernandez spatiotemporaldynamicsofhomologousrecombinationrepairatsinglecollapsedreplicationforks AT sarahkeegan spatiotemporaldynamicsofhomologousrecombinationrepairatsinglecollapsedreplicationforks AT davidfenyo spatiotemporaldynamicsofhomologousrecombinationrepairatsinglecollapsedreplicationforks AT elirothenberg spatiotemporaldynamicsofhomologousrecombinationrepairatsinglecollapsedreplicationforks |
_version_ |
1721449421011419136 |