Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures

Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures

Summary Pseudoachondroplasia and multiple epiphyseal dysplasia are genetic skeletal diseases resulting from mutations in cartilage structural proteins. Electron microscopy and immunohistochemistry previously showed that the appearance of the cartilage extracellular matrix (ECM) in targeted mouse mod...

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Bibliographic Details
Main Authors: Peter A. Bell, Raimund Wagener, Frank Zaucke, Manuel Koch, Julian Selley, Stacey Warwood, David Knight, Raymond P. Boot-Handford, David J. Thornton, Michael D. Briggs
Format: Article
Language:English
Published: The Company of Biologists 2013-06-01
Series:Biology Open
Subjects:
Cartilage
Genetic skeletal disease
Proteomics
Pseudoachondroplasia
Multiple epiphyseal dysplasia
Online Access:http://bio.biologists.org/content/2/8/802

Internet

http://bio.biologists.org/content/2/8/802

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