Aspirin Prevents Colorectal Cancer by Normalizing EGFR Expression

Aspirin Prevents Colorectal Cancer by Normalizing EGFR Expression

Background: Aspirin intake reduces the risk of colorectal cancer (CRC), but the molecular underpinnings remain elusive. Epidermal growth factor receptor (EGFR), which is overexpressed in about 80% of CRC cases, is implicated in the etiology of CRC. Here, we investigated whether aspirin can prevent C...

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Bibliographic Details
Main Authors: Haitao Li, Feng Zhu, Lisa A. Boardman, Lei Wang, Naomi Oi, Kangdong Liu, Xiang Li, Yang Fu, Paul J. Limburg, Ann M. Bode, Zigang Dong
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:EBioMedicine
Subjects:
Colorectal cancer
Familial adenomatous polyposis
Epidermal growth factor receptor
Cyclooxygenase-2
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415000869

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http://www.sciencedirect.com/science/article/pii/S2352396415000869

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