In Vivo Imaging of Hypoxia and Neoangiogenesis in Experimental Syngeneic Hepatocellular Carcinoma Tumor Model Using Positron Emission Tomography

In Vivo Imaging of Hypoxia and Neoangiogenesis in Experimental Syngeneic Hepatocellular Carcinoma Tumor Model Using Positron Emission Tomography

Introduction. Hypoxia-induced ανβ3 integrin and aminopeptidase N (APN/CD13) receptor expression play an important role in tumor neoangiogenesis. APN/CD13-specific 68Ga-NOTA-c(NGR), ανβ3 integrin-specific 68Ga-NODAGA-[c(RGD)]2, and hypoxia-specific 68Ga-DOTA-nitroimidazole enable the in vivo detectio...

Full description

Bibliographic Details
Main Authors: Adrienn Kis, Judit P. Szabó, Noémi Dénes, Adrienn Vágner, Gábor Nagy, Ildikó Garai, Anikó Fekete, Dezső Szikra, István Hajdu, Orsolya Matolay, Gábor Méhes, Gábor Mező, István Kertész, György Trencsényi
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2020/4952372

Internet

http://dx.doi.org/10.1155/2020/4952372

Similar Items