POLQ Overexpression Is Associated with an Increased Somatic Mutation Load and PLK4 Overexpression in Lung Adenocarcinoma

POLQ Overexpression Is Associated with an Increased Somatic Mutation Load and PLK4 Overexpression in Lung Adenocarcinoma

DNA Polymerase Theta (POLQ) is a DNA polymerase involved in error-prone translesion DNA synthesis (TLS) and error-prone repair of DNA double-strand breaks (DSBs). In the present study, we examined whether abnormal POLQ expression may be involved in the pathogenesis of lung adenocarcinoma (LAC). Firs...

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Bibliographic Details
Main Authors: Kazuya Shinmura, Hisami Kato, Yuichi Kawanishi, Katsuhiro Yoshimura, Kazuo Tsuchiya, Yoshiyuki Takahara, Seiji Hosokawa, Akikazu Kawase, Kazuhito Funai, Haruhiko Sugimura
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
lung adenocarcinoma
POLQ overexpression
PLK4 overexpression
somatic mutation load
centrosome amplification
translesion DNA synthesis
Online Access:https://www.mdpi.com/2072-6694/11/5/722

Internet

https://www.mdpi.com/2072-6694/11/5/722

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