Ubiquitin and Ubiquitin-Like Proteins Are Essential Regulators of DNA Damage Bypass

Many endogenous and exogenous factors can induce genomic instability in human cells, in the form of DNA damage and mutations, that predispose them to cancer development. Normal cells rely on DNA damage bypass pathways such as translesion synthesis (TLS) and template switching (TS) to replicate past...

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Bibliographic Details
Main Authors: Nicole A. Wilkinson, Katherine S. Mnuskin, Nicholas W. Ashton, Roger Woodgate
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/12/10/2848